The genetic regulation of transcription in human endometrial tissue

Abstract

STUDY QUESTION Do genetic effects regulate gene expression in human endometrium SUMMARY ANSWER This study demonstrated strong genetic effects on endometrial gene expression and some evidence for genetic regulation of gene expression in a menstrual cycle stage-specific manner. WHAT IS KNOWN ALREADY Genetic effects on expression levels for many genes are tissue specific. Endometrial gene expression varies across menstrual cycle stages and between individuals, but there are limited data on genetic control of expression in endometrium. STUDY DESIGN, SIZE, DURATION We analysed genome-wide genotype and gene expression data to map cis expression quantitative trait loci (eQTL) in endometrium. PARTIC..